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| Status |
Public on Jun 12, 2024 |
| Title |
The role of SMAD7 on epigenetic regulation of TGF-β targets in the metastasis of ovarian cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Targeting TGF-β signaling and its downstream effectors, such as SMAD7, may offer promising therapeutic strategies for reversing epigenetic alterations and inhibiting metastatic progression in ovarian cancer.
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| Overall design |
TGF-β signaling, a key regulator of EMT, may directly influence DNA methylation in the E-cadherin promoter. SMAD7 was overexpressed to investigate if sustained activation of TGF-β signaling contributes to DNA methylation of the E-cadherin promoter in ovarian cancer in a mesenchymal ovarian cancer cell
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| Contributor(s) |
Chan MY, Chen L |
| Citation missing |
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| |
| Submission date |
Jun 11, 2024 |
| Last update date |
Jun 12, 2024 |
| Contact name |
Hung-Cheng Lai |
| E-mail(s) |
hclai30656@gmail.com
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| Organization name |
Taipei Medical University
|
| Department |
Department of Obstetrics and Gynecology, School of Medicine, College of Medicine,
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| Street address |
No.250, Wuxing St.
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| City |
Taipei |
| ZIP/Postal code |
11031 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL28270 |
Illumina HumanHT-12 v4 Expression BeadChip [Array_Address_Id] |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1122794 |
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