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| Status |
Public on Jul 21, 2024 |
| Title |
The cholinergic receptor nicotinic α3 was reduced in the hippocampus of cognitively impaired old mice and upregulated by nicotine and cytisine in HT22 cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Microarrays were performed to facilitate a comparative analysis of the hippocampi in old mice exhibiting normal versus declined cognitive function.
The results demonstrated that the expression of the cholinergic receptor nicotinic α3 subunit (Chrna3) was significantly reduced in old mice with cognitive decline compared to control.
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| Overall design |
The hippocampus was extracted from C57BL7 mice.
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| Contributor(s) |
Ota H, Ohnuma T, Kodama A, Shimizu T, Sugawara K, Yamamoto F |
| Citation missing |
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| |
| Submission date |
Jul 16, 2024 |
| Last update date |
Jul 22, 2024 |
| Contact name |
Takako Ohnuma |
| E-mail(s) |
takakoohnuma@gmail.com
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| Phone |
0188017184
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| Organization name |
Akita University
|
| Department |
ARGG
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| Street address |
1-1-1, Hondo,
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| City |
Akita |
| State/province |
Akita |
| ZIP/Postal code |
010-8543 |
| Country |
Japan |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA1136455 |
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