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Status |
Public on Sep 15, 2024 |
Title |
Effect of mutant GNAS expression in the doxycycline-inducible Kras;Gnas mouse model of IPMN using scRNA-seq |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
We investigated the effect of GNAS(R201C) expression in the Kras;Gnas model of pancreatic intraductal papillary mucinous neoplasms where transgenic mutant GNAS is doxycycline inducible (LGKC; p48(Cre), Kras(LSL-G12D), Rosa26(LSL-rtTA)), Tg(TetO-GNAS(R201C)) using scRNA-seq of dissociated pancreatic tissues.
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Overall design |
Four Kras;Gnas mice were fed with doxycycline or normal lab feed for 10 weeks starting at 8 weeks of age (2 mice per group). Pancreata were dissociated and subjected to scRNA-seq.
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Contributor(s) |
Makino Y, Rajapakshe K, Maitra A, Thege F |
Citation(s) |
39277181 |
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Submission date |
Aug 21, 2024 |
Last update date |
Sep 16, 2024 |
Contact name |
Anirban Maitra |
E-mail(s) |
AMaitra@mdanderson.org
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Organization name |
The University of Texas MD Anderson Cancer Center
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Department |
Translational Molecular Pathology
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Lab |
Maitra laboratory
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Street address |
6565 MD Anderson Blvd
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City |
Houston |
State/province |
TX |
ZIP/Postal code |
77030 |
Country |
USA |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (4)
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This SubSeries is part of SuperSeries: |
GSE275406 |
IPMN model mice with Kras;Gnas mutation |
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Relations |
BioProject |
PRJNA1150613 |