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Series GSE275422 Query DataSets for GSE275422
Status Public on Aug 21, 2024
Title Aristolochic acid-related renal cell carcinoma exhibits a distinct tumor immune microenvironment and may be more responsive to immune checkpoint blockade
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We aimed to investigate the immune profile of AA-related RCC and explore its potential role as a predictive biomarker for ICB. Three distinct clusters were found through functional pathway analysis using the NanoString gene expression panel. AA-positive ccRCC comprised the majority of cluster 1 and 3, and the two patients with good response to ICB were grouped to Cluster 3. Cluster 3 exhibited higher tumor inflammation signature (TIS) and immune cell type scores.
 
Overall design Tissue samples from two patients with metastatic RCC (mRCC) who responded well to ICB and twenty-two additional tumor-normal tissue paired clear cell renal cell carcinoma (ccRCC) were profiled for gene expressions using NanoString PanCancer IO360.
 
Contributor(s) Lin P
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Submission date Aug 21, 2024
Last update date Aug 22, 2024
Contact name Abner Lim
E-mail(s) abner.lim.m.s@nccs.com.sg
Organization name National Cancer Center Singapore
Department Division of Medical Oncology
Lab Cancer Discovery Hub
Street address 30 Hospital Boulevard
City Singapore
ZIP/Postal code 168583
Country Singapore
 
Platforms (1)
GPL32069 NanoString Human nCounter PanCancer IO360 Panel
Samples (24)
GSM8476648 Tissue sample from mRCC patient with ICB treatment RCC1
GSM8476649 Tissue sample from mRCC patient with ICB treatment RCC2
GSM8476650 Tissue sample from ccRCC patient ccRCC23
Relations
BioProject PRJNA1150641

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE275422_RAW.tar 230.0 Kb (http)(custom) TAR (of RCC)

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