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| Status |
Public on Aug 31, 2024 |
| Title |
Identify WT and p53 3KR target in basal progenitor cells of epidermis |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Unbalanced and growth promoting cell fate dynamics that follow p53 loss, and the inability of canonical p53 functions to restrict clonal expansion, suggest the existence of a non-canonical p53 transcriptional program that controls key cell fate regulators. We hypothesized that these cell fate genes are among the shared targets of p53WT and p533KR.
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| Overall design |
p53 ChIP-seq performed in isolated epidermal basal progenitor cells of p53WT and p533KR animals, 25uM of Nutlin-3a were added to digestion medium to stabilize p53
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| Contributor(s) |
Ying Z, Beronja S |
| Citation missing |
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| |
| Submission date |
Aug 27, 2024 |
| Last update date |
Aug 31, 2024 |
| Contact name |
Zhe Ying |
| E-mail(s) |
zhe.ying@mssm.edu
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| Phone |
2063196752
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| Organization name |
Icahn School of Medicine at Mount Sinai
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| Department |
Department of Cell, Developmental and Regenerative Biology
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| Lab |
Ying
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| Street address |
Madison Avenue 1468
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1152794 |
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