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Series GSE27576 Query DataSets for GSE27576
Status Public on Jun 26, 2012
Title Profile of small RNA transcriptome during cortical development in the Rat
Organism Rattus norvegicus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Small non-coding RNAs play important roles in regulating gene expression during development and disease. However, a comprehensive analysis of small RNAs in developing brain is largely lacking. By using next-generation sequencing technique, we carried out a systematic analysis of small RNA transcriptome of rat neocortex from early developmental stage till adult. Our results revealed an extraordinary degree of stage-specific profiling of miRNA, and other classes of small RNAs including snoRNA, rasRNA, scRNA and unexpectedly piRNA, which was considered to be solely expressed in germline tissues. Developmentally regulated miRNA editing was also observed. This study further showed the effectiveness of the high through-put sequencing in genome-wide analysis of small RNAs. The dataset described here will greatly contribute to our understanding of the divergence, variation, and function of small RNAs and may be a valuable resource in clarifying new regulatory mechanisms of cortical development.
 
Overall design Identification and quantification of small RNA: forebrain and cortex from E10 to P28
 
Contributor(s) Xiaobing Y, Maojin Y, Gang C
Citation(s) 22691069
Submission date Feb 28, 2011
Last update date Jun 11, 2013
Contact name Maojin Yao
E-mail(s) mjyao@ion.ac.cn
Organization name Institute of Neurosciecne
Department Neural circuit development
Street address 320# Yueyang Road
City Shanghai
ZIP/Postal code 200031
Country China
 
Platforms (1)
GPL13235 Illumina genome Analyzer II (Rattus norvegicus)
Samples (18)
GSM683700 Forebrain_Embryonic day 10_Technical replicate_1
GSM683701 Forebrain_Embryonic day 10_Technical replicate_2
GSM683702 Forebrain_Embryonic day 13_Technical replicate_1
Relations
BioProject PRJNA138383

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27576_RAW.tar 43.5 Mb (http)(custom) TAR (of TXT)
Processed data provided as supplementary file
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