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| Status |
Public on Sep 22, 2024 |
| Title |
Gene expression of wild-type or GC-A knockout mouse glomeruli treated with high salt diet and aldosterone infusion after uninephrectomy. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Podocytes are integral to maintaining the glomerular filtration barrier and preventing proteinuria. Our previous research underscored the crucial role of podocyte guanylyl cyclase-A (GC-A) in the pathogenesis of severe albuminuria in both systemic and podocyte-specific GC-A knockout mice.
In this study, we demonstrate that matrix metalloproteinase-10 (MMP-10) is highly expressed in the glomeruli of GC-A knockout mice and in the kidneys of patients with glomerulonephritis.
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| Overall design |
Systemic GC-A knockout and wild-type mice were performed uninephrectomy before aldosterone infusion and high salt diet for 3 weeks. Total glomerular RNA from these mice was subjected to microarray assay
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| Contributor(s) |
Ishimura T, Osaki K, Ogawa Y, Yokoi H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 07, 2024 |
| Last update date |
Sep 23, 2024 |
| Contact name |
Takuya Ishimura |
| E-mail(s) |
t_ishimura@kuhp.kyoto-u.ac.jp
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| Organization name |
Kyoto University
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| Department |
Nephrology
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| Lab |
Yokoi Laboratory
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| Street address |
Sakyo-ku Syogoinkawaharatyo 54
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| City |
Kyoto |
| State/province |
Kyoto |
| ZIP/Postal code |
6068507 |
| Country |
Japan |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1158247 |
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