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| Status |
Public on May 12, 2011 |
| Title |
Expression data from LSK WT and LSK N1-C+ |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is controlled by the gamma-secretase complex complex, composed of presenilin, nicastrin (Ncstn), anterior pharynx-1 (Aph1), and presenilin enhancer-2
To determine other role of Notch signaling in HSC we designed a conditional mouse model of Notch activation. WT and N1-IC+ HSC were analysed to determined genes controlled by Notch signaling.
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| Overall design |
Bone marrow lineage negative, cKit+, Sca1+ cells were sorted from WT and N1-IC+ littermates for RNA extraction and hybridization on Affymetrix microarrays
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| Contributor(s) |
Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, Liu C, Ibrahim S, Beran M, Zavadil J, Efstratiadis A, Taghon T, Michor F, Levine RL, Aifantis I |
| Citation(s) |
21562564 |
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| Submission date |
Mar 07, 2011 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Camille Lobry |
| E-mail(s) |
camille.lobry@inserm.fr
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| Organization name |
Inserm
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| Department |
IRSL Inserm U944 / CNRS UMR7212
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| Lab |
Lobry lab
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| Street address |
16 rue de la Grange aux Belles
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| City |
Paris |
| ZIP/Postal code |
75010 |
| Country |
France |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA141799 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE27799_RAW.tar |
23.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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