NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE28167 Query DataSets for GSE28167
Status Public on Mar 25, 2011
Title Topography-dependent gene expression in migratory glioma cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The goal of this experiment was to compare the gene expression of glioma cells migrating on substrates of different topographies and to determine a migration-associated gene profile.
Human malignant glioma U251MG cells were cultured on highly-aligned versus randomly-oriented electrospun nanofibers of poly-caprolactone. Cells migrated actively on aligned
nanofibers but motility was very restricted on randomly-oriented fibers. Results of gene expression profiling indicated upregulation of a JAK/STAT signature in actively migrating glioma cells.
 
Overall design Total RNA was extracted from 3 independent cultures of U251 glioma cells cultured on aligned versus random nanofibers and applied to Affymetrix HG-U133 plus 2 chips.
Analysis of gene expression was used to determine a gene-signature correlated with different substrate topography
 
Contributor(s) Viapiano MS, Lawler SE, Liyanarachchi S
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Mar 24, 2011
Last update date Mar 25, 2019
Contact name Mariano Sebastian Viapiano
E-mail(s) viapiano.1@osu.edu
Phone 614-292-4362
Fax 614-292-5379
URL http://www.viapianolab.org
Organization name The Ohio State University
Department Neurological Surgery
Street address 1060 Carmack Rd
City Columbus
State/province OH
ZIP/Postal code 43210
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (6)
GSM697600 U251 aligned 1
GSM697601 U251 aligned 2
GSM697602 U251 aligned 3
Relations
BioProject PRJNA139515

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28167_RAW.tar 28.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
External link. Please review our privacy policy.