|
| Status |
Public on Mar 26, 2011 |
| Title |
Expression data from HAART interruption in HIV patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We evaluated longitudinal changes in viral replication and emergence of viral variants in the context of T cell homeostasis and gene expression in GALT of three HIV-positive patients who initiated HAART during primary HIV infection but opted to interrupt therapy thereafter. Longitudinal viral sequence analysis revealed that a stable proviral reservoir was established in GALT during primary HIV infection that persisted through early HAART and post-therapy interruption. Proviral variants in GALT and peripheral blood mononuclear cells (PBMCs) displayed low levels of genomic diversity at all times. A rapid increase in viral loads with a modest decline of CD4 T cells in peripheral blood was observed, while gut mucosal CD4 T cell loss was severe following HAART interruption. This was accompanied by increased mucosal gene expression regulating interferon (IFN)-mediated antiviral responses and immune activation, a profile similar to those found in HAART-naive HIV-infected patients.
|
| |
|
| Overall design |
Gut mucosal responses to HAART interruption were evaluated with Affymetrix arrays
|
| |
|
| Contributor(s) |
George MD |
| Citation(s) |
21345945 |
| |
| Submission date |
Mar 25, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Michael George |
| E-mail(s) |
mdgeorge@ucdavis.edu
|
| Organization name |
University of California, Davis
|
| Department |
Medical Microbiology and Immunology
|
| Street address |
451 Health Sciences Drive
|
| City |
Davis |
| State/province |
CA |
| ZIP/Postal code |
95616 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (6)
|
| GSM697651 |
uninfected control, biological replicate 1 |
| GSM697652 |
uninfected control, biological replicate 2 |
| GSM697653 |
uninfected control, biological replicate 3 |
| GSM697654 |
HIV infected patient, biological replicate 1 |
| GSM697655 |
HIV infected patient, biological replicate 2 |
| GSM697656 |
HIV infected patient, biological replicate 3 |
|
| Relations |
| BioProject |
PRJNA139527 |
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