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| Status |
Public on Jun 17, 2013 |
| Title |
Screening Hub Genes Related to the Recovery Phase of Irradiation Injury by Microarray Analysis Combined with Integrated Gene Network |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Microarray analysis was used to identify the differentially expressed genes. Bioinformatics analyses integrated with databases and text-mined gene network were conducted to understand irradiation-related hub genes, pathways and biological processes. Our hypothesis in these paper are: 1) the expression profiles of irradiation damaged bone marrow tissue are not identical in injury phase and recovery phase; and 2) some hub genes potentially vital to BM recovery can be screened out by means of microarray analysis and bioinformatics analysis. The results provide basic information to explain the radiation-related biological processes and hub genes.
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| Overall design |
The five mRNA samples in total bone marrow cells were profiled by using gene chip at 3, 7, 11 and 21 days after irradiation and 0 day (sham-irradiation) as control. Each time point contains one sample.
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| |
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| Contributor(s) |
Zhang J, Yang Y, Wang Y, Zhang J, Wang Z, Yin M, Shen X |
| Citation(s) |
21931809 |
| |
| Submission date |
Mar 27, 2011 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Ming Yin |
| E-mail(s) |
myin@sjtu.edu.cn
|
| Phone |
86-21-34206836
|
| Fax |
86-21-34204457
|
| Organization name |
Shanghai Jiao Tong University
|
| Department |
School of Pharmacy
|
| Lab |
Lab of Neuropharmacology
|
| Street address |
No.800 RD Dongchuan
|
| City |
Shanghai |
| ZIP/Postal code |
200240 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (5)
|
| GSM698082 |
bone marrow_sham-irradiated_0 day_rep1 |
| GSM698083 |
bone marrow_irradiated_3 day_rep1 |
| GSM698084 |
bone marrow_irradiated_7 day_rep1 |
|
| Relations |
| BioProject |
PRJNA139629 |
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