|
| Status |
Public on Apr 09, 2011 |
| Title |
Characterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors.
Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alterations.
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| |
|
| Overall design |
We compared gene expression profiles of AA with (n: 3) and without (n: 4) CTNNB1 mutations using Affymetrix arrays.
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| |
|
| Contributor(s) |
Durand J, Bourdeau I |
| Citation(s) |
21565795 |
| |
| Submission date |
Apr 08, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
julien durand |
| E-mail(s) |
juliend667@gmail.com
|
| Phone |
514-890-8000
|
| Organization name |
CRCHUM
|
| Department |
Biomedicale Science
|
| Street address |
3840 Rue Saint-Urbain
|
| City |
Montreal |
| State/province |
QC |
| ZIP/Postal code |
H2W 1T8 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (8)
|
| GSM703788 |
Pool of 62 normal adrenal glands |
| GSM703789 |
Adrenocortical adenoma with CTNNB1 mutation (S45P) |
| GSM703790 |
Adrenocortical adenoma with CTNNB1 mutation (T41A) |
| GSM703791 |
Adrenocortical adenoma with CTNNB1 mutation_(S37C) |
| GSM703792 |
Adrenocortical adenoma with wild-type CTNNB1-1 |
| GSM703793 |
Adrenocortical adenoma with wild-type CTNNB1-2 |
| GSM703794 |
Adrenocortical adenoma with wild-type CTNNB1-3 |
| GSM703795 |
Adrenocortical adenoma with wild-type CTNNB1-4 |
|
| Relations |
| BioProject |
PRJNA139317 |
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