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Series GSE28734 Query DataSets for GSE28734
Status Public on May 19, 2011
Title Genome wide H3K9ac and SAGA occupancy at OX growth phase and RC quiescent phase of yeast metabolic cycle
Organism Saccharomyces cerevisiae
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We found acetyl-CoA levels increase when cells are committed to growth. We also found 3 components of the SAGA complex, Spt7p, Sgf73p and Ada3p as well as histones are dynamically acetylated in tune with the acetyl-CoA levels. ChIP-seq study reveals SAGA and H3K9ac predominantly occupy growth genes at the OX growth phase of the yeast metabolic cycle indicating acetyl-CoA levels may drive growth gene transcription program through acetylation of these proteins.
Overall design Examination of H3K9ac and SAGA binding over two timepoints using H3 and Input as controls
Contributor(s) Cai L, Tu BP
Citation(s) 21596309
Submission date Apr 20, 2011
Last update date May 15, 2019
Contact name Ling Cai
Organization name UT Southwestern Medical Center at Dallas
Street address 5323 Harry Hines Boulevard
City Dallas
State/province TX
ZIP/Postal code 75390
Country USA
Platforms (1)
GPL9134 Illumina Genome Analyzer (Saccharomyces cerevisiae)
Samples (8)
GSM711896 H3K9ac_OX_ChIP-seq
GSM711897 H3K9ac_RC_ChIP-seq
GSM711898 H3_OX_ChIP-seq
SRA SRP006461
BioProject PRJNA140547

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28734_RAW.tar 13.1 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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