|
| Status |
Public on May 19, 2011 |
| Title |
Genome wide H3K9ac and SAGA occupancy at OX growth phase and RC quiescent phase of yeast metabolic cycle |
| Organism |
Saccharomyces cerevisiae |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We found acetyl-CoA levels increase when cells are committed to growth. We also found 3 components of the SAGA complex, Spt7p, Sgf73p and Ada3p as well as histones are dynamically acetylated in tune with the acetyl-CoA levels. ChIP-seq study reveals SAGA and H3K9ac predominantly occupy growth genes at the OX growth phase of the yeast metabolic cycle indicating acetyl-CoA levels may drive growth gene transcription program through acetylation of these proteins.
|
| |
|
| Overall design |
Examination of H3K9ac and SAGA binding over two timepoints using H3 and Input as controls
|
| |
|
| Contributor(s) |
Cai L, Tu BP |
| Citation(s) |
21596309 |
| |
| Submission date |
Apr 20, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Ling Cai |
| E-mail(s) |
ling.cai@utsouthwestern.edu
|
| Organization name |
UT Southwestern Medical Center at Dallas
|
| Street address |
5323 Harry Hines Boulevard
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9134 |
Illumina Genome Analyzer (Saccharomyces cerevisiae) |
|
| Samples (8)
|
|
| Relations |
| SRA |
SRP006461 |
| BioProject |
PRJNA140547 |
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