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| Status |
Public on Jun 01, 2011 |
| Title |
Expression data of small intestine crypts and villi from mice with nutritional and genetic risk factors for intestinal tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Nutritional and genetic risk factors for intestinal tumors are additive on mouse tumor phenotypes, demonstrating that diet and genetic factors impact risk by distinct combinatorial mechanisms. We analyzed expression profiles of small intestine crypts and villi from mice with nutritional and genetic risk factors. The results advanced our understanding of the mechanistic roles played by major risk factors in the pathogenesis of intestinal tumors.
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| Overall design |
Small intestine crypts and villi from mice with nutritional (Ain76A, NWD1, and NWD2) and genetic risk factors (WT, Apc1638N/+ and p21-/-) were collected for RNA extraction and analysis using the Affymetrix 3' IVT expression microarray. Three or four replicates per tissue/risk factor.
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| Contributor(s) |
Wang D, Peregrina K, Dhima E, Lin EY, Mariadason JM, Augenlicht LH |
| Citation(s) |
21652773 |
| |
| Submission date |
May 25, 2011 |
| Last update date |
Feb 11, 2019 |
| Contact name |
DONGHAI WANG |
| E-mail(s) |
dhwang78@gmail.com, leonard.augenlicht@einstein.yu.edu
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| Organization name |
Montefiore Medical Center
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| Street address |
111 E210 St
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| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10467 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (47)
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| Relations |
| BioProject |
PRJNA141437 |
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