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| Status |
Public on Dec 25, 2012 |
| Title |
Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Here, we investigated whether prenatal exposure to nicotine alters kidney glomerular mass and genome-wide gene expression profiles in two genetically distant strains of rats, namely spontaneously hypertensive rats (SHR) and Brown Norway (BN) rats. Nicotine or saline were administered to BN and SHR dams via osmotic pumps throughout gestation. Kidneys from 9-week-old male offspring were studied.
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| Overall design |
Equal amounts of RNA from individual animals were pooled within each of the four experimental groups SHR (nicotine: n=13; saline: n=12) and BN (nicotine: n=12; saline: n=12) and hybridized with the Rat RAE-230a GeneChip (Affymetrix).
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| Contributor(s) |
Arab S, Pausova Z |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 01, 2011 |
| Last update date |
Mar 03, 2017 |
| Contact name |
Sara Arab |
| Organization name |
Toronto General Hospital
|
| Department |
Cardiology
|
| Lab |
M. Husain
|
| Street address |
610 University Avenue
|
| City |
Toronto |
| State/province |
ONT |
| ZIP/Postal code |
M5G 2M9 |
| Country |
Canada |
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| Platforms (1) |
| GPL341 |
[RAE230A] Affymetrix Rat Expression 230A Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA141197 |
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