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| Status |
Public on Aug 01, 2014 |
| Title |
Expression data from LCL samples from patients with global developmental delay and autistic features and normal controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We analyzed the whole-genome mRNA expression profiling of cultured lymphoblastoid cell lines (LCLs) from patients (n=2), carriers (n=2), and unrelated normal controls (n=3), all performed in duplicates using Affymetrix GeneChip Human Exon 1.0 ST arrays, to identify genes and pathways that are significantly dysregulated in affected individuals. Moreover, we have performed global transcriptional profiling in whole blood from patients (n=2) and healthy controls (n=13) using Affymetrix GeneChip Human Genome U133 Plus 2.0 arrays. Global transcriptional profiling of affected individuals and controls revealed significant alterations of genes and pathways in a pattern consistent with previous microarray studies of autism spectrum disorder patients.
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| Overall design |
Genome-wide gene-level expression changes for samples from cultured lymphoblastoid cell lines from patients with global developmental delay and autistic features (n=2), carriers (n=2), and unrelated healthy controls (n=3), all performed in duplicate, using Affymetrix GeneChip® Human Exon 1.0 ST arrays.
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| Contributor(s) |
Colak D, Kaya N |
| Citation(s) |
22213401 |
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| Submission date |
Jun 13, 2011 |
| Last update date |
Feb 21, 2024 |
| Contact name |
Dilek Colak |
| E-mail(s) |
dkcolak@gmail.com
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| Phone |
96614426286
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| Organization name |
KFSHRC
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| Department |
Biostatistics, Epidemiology and Scientific Computing
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| Street address |
MBC03, PO Box 3354
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| City |
Riyadh |
| ZIP/Postal code |
11211 |
| Country |
Saudi Arabia |
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| Platforms (1) |
| GPL5175 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (14)
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| GSM740842 |
Control3, biol rep2 |
| GSM740843 |
Control4, biol rep1 |
| GSM740844 |
Control4, biol rep2 |
| GSM740845 |
Index1, biol rep1 |
| GSM740846 |
Index1, biol rep2 |
| GSM740847 |
Index2, biol rep1 |
| GSM740848 |
Index2, biol rep2 |
| GSM740849 |
Carrier1, biol rep1 |
| GSM740850 |
Carrier1, biol rep2 |
| GSM740851 |
Carrier2, biol rep1 |
| GSM740852 |
Carrier2, biol rep2 |
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| This SubSeries is part of SuperSeries: |
| GSE29919 |
Whole-genome mRNA expression profiling of cultured lymphoblastoid cell lines (LCLs) and whole blood from patients with global developmental delay and autistic features and unrelated normal controls |
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| Relations |
| BioProject |
PRJNA155329 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29918_RAW.tar |
287.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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