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Status |
Public on Jul 07, 2011 |
Title |
HIV Infection and Antiretroviral Therapy Have Divergent Effects on Mitochondria in Adipose Tissue |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Exploratory microarray analysis identified significant changes in gene expression in adipose tissue. These included changes in genes regulating lipid and steroid metabolic processes and electron carrier activity in HIV-infected patients receiving antiretroviral therapy (ART). Additional genes involved in metabolic processes and mitochondrial function were found to be up-regulated in the adipose tissue of HIV-positive patients compared with HIV-negative controls.
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Overall design |
To identify differential gene expression in different tissues (PBMC, muscle, adipose tissue) between HIV patient groups (HIV negative, HIV positive with ART, HIV positive without ART).
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Contributor(s) |
Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, Hu X, Yang J, Huang DW, Logun C, Danner RL, Rangel ZG, Munson PJ, Orenstein JM, Rushing EJ, Lempicki RA, Dalakas MC, Kovacs JA |
Citation(s) |
22476717 |
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Submission date |
Jun 29, 2011 |
Last update date |
Nov 20, 2012 |
Contact name |
Richard A Lempicki |
E-mail(s) |
rlempicki@mail.nih.gov
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Phone |
301-846-5093
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Organization name |
Leidos Biomedical Research, Inc.
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Department |
Clinical Services Program
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Lab |
Laboratory of Immunopathogenesis and Bioinformatics
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Street address |
PO Box B
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City |
Frederick |
State/province |
MD |
ZIP/Postal code |
21702 |
Country |
USA |
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Platforms (1) |
GPL9392 |
Affymetrix human mitochondrial array [CDF: FATMITO1a520158F] |
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Samples (166)
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Relations |
BioProject |
PRJNA143573 |
Supplementary file |
Size |
Download |
File type/resource |
GSE30310_RAW.tar |
72.0 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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