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Series GSE30310 Query DataSets for GSE30310
Status Public on Jul 07, 2011
Title HIV Infection and Antiretroviral Therapy Have Divergent Effects on Mitochondria in Adipose Tissue
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Exploratory microarray analysis identified significant changes in gene expression in adipose tissue. These included changes in genes regulating lipid and steroid metabolic processes and electron carrier activity in HIV-infected patients receiving antiretroviral therapy (ART). Additional genes involved in metabolic processes and mitochondrial function were found to be up-regulated in the adipose tissue of HIV-positive patients compared with HIV-negative controls.
 
Overall design To identify differential gene expression in different tissues (PBMC, muscle, adipose tissue) between HIV patient groups (HIV negative, HIV positive with ART, HIV positive without ART).
 
Contributor(s) Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, Hu X, Yang J, Huang DW, Logun C, Danner RL, Rangel ZG, Munson PJ, Orenstein JM, Rushing EJ, Lempicki RA, Dalakas MC, Kovacs JA
Citation(s) 22476717
Submission date Jun 29, 2011
Last update date Nov 20, 2012
Contact name Richard A Lempicki
E-mail(s) rlempicki@mail.nih.gov
Phone 301-846-5093
Organization name Leidos Biomedical Research, Inc.
Department Clinical Services Program
Lab Laboratory of Immunopathogenesis and Bioinformatics
Street address PO Box B
City Frederick
State/province MD
ZIP/Postal code 21702
Country USA
 
Platforms (1)
GPL9392 Affymetrix human mitochondrial array [CDF: FATMITO1a520158F]
Samples (166)
GSM751293 PBMC_Pt1_HIV+_No_ART
GSM751294 PBMC_Pt11_HIV+_ART
GSM751295 PBMC_Pt14_HIV+_No_ART
Relations
BioProject PRJNA143573

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30310_RAW.tar 72.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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