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| Status |
Public on Jun 30, 2011 |
| Title |
Expression data from mouse heart with and without GATA4 S105A mutation; with and without adrenergic stress |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Serine 105 phosphorylation of GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.
We used microarrays to detail global gene expression program alterations that arise in response to the ablation of the Gata4 S105 phosphorylation site in basal and adrenergic-stressed heart ventricles.
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| Overall design |
Wildtype and genetically engineered mice were subjected to control or pseudoephedrine treatment and heart ventricle RNAs were extracted and hybridized on Affymetrix microarrays. Comparisons consisted of identifying treatment- and genotype-affected gene expression patterns.
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| Contributor(s) |
Aronow BJ, van Berlo JH, Pu WT, Elrod J, Molkentin JD |
| Citation(s) |
21746915 |
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| Submission date |
Jun 29, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Bruce J Aronow |
| E-mail(s) |
bruce.aronow@chmcc.org
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| Phone |
513-636-4865
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| Organization name |
Cincinnati Children's Hospital Medical Center
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| Street address |
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| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| GSM751508 |
WT, untreated whole heart, individual 1 |
| GSM751509 |
WT, untreated whole heart, individual 2 |
| GSM751510 |
WT, PE treated whole heart, individual 3 |
| GSM751511 |
WT, PE treated whole heart, individual 4 |
| GSM751512 |
Gata4_S105Amut, untreated whole heart, individual 5 |
| GSM751513 |
Gata4_S105Amut, untreated whole heart, individual 6 |
| GSM751514 |
Gata4_S105Amut, PE treated whole heart, individual 7 |
| GSM751515 |
Gata4_S105Amut, PE treated whole heart, individual 8 |
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| Relations |
| BioProject |
PRJNA143567 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30314_RAW.tar |
34.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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