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Series GSE30427 Query DataSets for GSE30427
Status Public on Mar 14, 2012
Title Expression analysis of mouse thyroid tumors
Organism Mus musculus
Experiment type Expression profiling by array
Summary Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer, and often derives from pre-existing well-differentiated tumors. We have engineered the first mouse model of ATC by combining in the mouse thyroid follicular cells two molecular hallmarks of human ATC: activation of PI3K (via Pten deletion) and inactivation of p53. By 9 months of age, over 75% of the compound mutant mice develop aggressive, undifferentiated thyroid tumors that evolve from pre-existing follicular hyperplasia and carcinoma. These tumors display all the features of their human counterpart, including pleomorphism, epithelial-mesenchymal transition, aneuploidy, local invasion and distant metastases.
 
Overall design We have performed expression profiling of thyroids from control, single mutants, compound mutants, follicular tumors from Pten-/- mice and [Pten-/-,KrasG12D] mice, and anaplastic tumors from Pten, p53-/- mice.
 
Contributor(s) Di Cristofano A, Russo M
Citation(s) 22190384, 23751876
Submission date Jul 06, 2011
Last update date Mar 04, 2019
Contact name Antonio Di Cristofano
E-mail(s) antonio.dicristofano@einstein.yu.edu
Phone 718-678-1137
Fax 718-678-1020
Organization name Albert Einstein College of Medicine
Department Developmental and Molecular Biology
Street address 1301 Morris Park Ave Price 302
City Bronx
State/province NY
ZIP/Postal code 10461
Country USA
 
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (31)
GSM754701 wild type male biological replicate 1
GSM754702 wild type male biological replicate 2
GSM754703 wild type male biological replicate 3
Relations
BioProject PRJNA143527

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30427_RAW.tar 144.2 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
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