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| Status |
Public on Sep 14, 2011 |
| Title |
Dual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer [ChIP_seq, DHS_seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We report the dual role of FoxA1 in androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell line LNCaP-1F5 using ChIP-sequencing. Depletion of FoxA1 reprograms both androgen and glucocorticoid receptor recruitment and subsequent gene expression. The ChIP-seq has been performed using AR, FoxA1, GR, H3K4me2 antibodies. We have also mapped the DNaseI-hypersensitive sites (DHS) using deep sequencing.
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| Overall design |
Examination of AR, FoxA1, GR, H3K4me2 binding sites and DHS sites in parental and FoxA1 depleted LNCaP-1F5 cells.
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| Contributor(s) |
Sahu B, Laakso M, Ovaska K, Mirtti T, Lundin J, Rannikko A, Sankila A, Turunen J, Lundin M, Konsti J, Vesterinen T, Nordling S, Kallioniemi O, Hautaniemi S, Jänne OA |
| Citation(s) |
21915096 |
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| Submission date |
Jul 12, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Olli A. Jänne |
| E-mail(s) |
olli.janne@helsinki.fi
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| Phone |
+358919125040
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| Organization name |
University of Helsinki
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| Department |
Inst. of Biomedicine/Physiology
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| Lab |
Androgen Receptor Laboratory
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| Street address |
Haartmaninkatu-8
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| City |
Helsinki |
| ZIP/Postal code |
FI-00014 |
| Country |
Finland |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (15)
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| This SubSeries is part of SuperSeries: |
| GSE30624 |
Dual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer |
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| Relations |
| SRA |
SRP007486 |
| BioProject |
PRJNA154785 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30623_RAW.tar |
8.5 Gb |
(http)(custom) |
TAR (of BED, SAM, TXT, WIG) |
| GSE30623_TFAS_peaks_txt.tar.gz |
622.3 Kb |
(ftp)(http) |
TAR |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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