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| Status |
Public on Mar 07, 2012 |
| Title |
Novel targets of microRNA miR-142 in cardiac myocytes |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
The nuclear acetyltransferase p300 is a dose-dependent and limiting regulator of cardiac hypertrophy. p300 regulates hypertrophy by controlling the expression of specific microRNAs.The objective of this study was to dissect the role of miR-142 during p300 regulated hypertophic growth in vitro and in vivo and to verify its targets.
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| |
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| Overall design |
MiR142 and a non target control were overexpressed using lentivirus in primary culture of neonatal cardiac myocytes. Overexpression was checked 48 hour post transfection. Samples include miR142 OE and non target from three different experiments.
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| |
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| Contributor(s) |
Sharma S, Bishopric NH |
| Citation(s) |
22367739 |
| |
| Submission date |
Aug 02, 2011 |
| Last update date |
Mar 23, 2012 |
| Contact name |
Salil Sharma |
| E-mail(s) |
ssharma2@med.miami.edu
|
| Organization name |
University of Miami
|
| Department |
Molecular and Cellular Pharmacology
|
| Lab |
Bishopric
|
| Street address |
1600 NW 10th Ave
|
| City |
Miami |
| State/province |
Florida |
| ZIP/Postal code |
33136 |
| Country |
USA |
| |
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| Platforms (1) |
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| Samples (6)
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| GSM770670 |
Rat cardiac myocytes miR142OE 48 hrs-1 |
| GSM770671 |
Rat cardiac myocytes miR142OE 48 hrs-2 |
| GSM770672 |
Rat cardiac myocytes miR142OE 48 hrs-3 |
| GSM770673 |
Rat cardiac myocytes Non target 48 hrst-1 |
| GSM770674 |
Rat cardiac myocytes Non target 48 hrs-2 |
| GSM770675 |
Rat cardiac myocytes Non target 48 hrs-3 |
|
| Relations |
| BioProject |
PRJNA144955 |
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