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| Status |
Public on Feb 23, 2012 |
| Title |
miRNA expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted comprehensive miRNA expression profiling in 40 ATL patients and in 22 healthy volunteers.
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| Overall design |
Total RNA samples from PBMC of ATL patients (mostly HTLV-1 inefcted CD4+ T-cells) and from CD4+ T-cells from healthy donors were subjected to Cy-3 labeling followed by miRNA expression microarray analyses.
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| Contributor(s) |
Tsutsumi A, Kagami Y, Nakano K, Yamagishi M, Uchimaru K, Utsunomiya A, Yamaguchi K, Watanabe T |
| Citation(s) |
22264793 |
| |
| Submission date |
Aug 24, 2011 |
| Last update date |
Jan 23, 2013 |
| Contact name |
Kazumi Nakano |
| Organization name |
The University of Tokyo
|
| Department |
Department of Medical Genome Sciences, Graduate School of Frontier Sciences
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| Lab |
Laboratory of Tumor Cell Biology
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| Street address |
4-6-1, Sirokanedai, Minatoku
|
| City |
Tokyo |
| ZIP/Postal code |
108-8639 |
| Country |
Japan |
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| Platforms (1) |
| GPL7731 |
Agilent-019118 Human miRNA Microarray 2.0 G4470B (Feature Number version) |
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| Samples (62)
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| Relations |
| BioProject |
PRJNA145549 |
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