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| Status |
Public on Jun 08, 2012 |
| Title |
Genome wide identification of p63 binding sites in human neonatal foreskin keratinocytes |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We report here genome wide identification of p63 binding sites in cycling neonatal foreskin keratinocytes using high throughput sequencing of ChIP enriched DNA. Analysis of gene ontology, database mining with integration with publicly available data, reveals a role for p63 in transcriptional regulation of multiple genes genetically linked to cleft palate. In addition, we identify AP-2α, a transcription factor which, when mutated, also results in craniofacial clefting syndrome, as a co-regulator of p63 responsive genes.
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| Overall design |
Examination of p63 binding sites in neonatal foreskin keratinocytes
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| Contributor(s) |
McDade SS, McCance DJ |
| Citation(s) |
22573176 |
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| Submission date |
Sep 12, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Simon S McDade |
| Organization name |
Queen's University Belfast
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| Department |
CCRCB
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| Street address |
97 Lisburn Road
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| City |
Belfast |
| ZIP/Postal code |
BT9 7BL |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL9115 |
Illumina Genome Analyzer II (Homo sapiens) |
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| Samples (4)
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| Relations |
| SRA |
SRP008483 |
| BioProject |
PRJNA147615 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32061_RAW.tar |
460.4 Mb |
(http)(custom) |
TAR (of BED, WIG) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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