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| Status |
Public on Jan 12, 2012 |
| Title |
Fiorentino 2006-7 dermatomyositis, lupus, control skin |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Background: Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood.
Methodology and Findings: We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of interferon (IFN)-inducible genes in DM skin, as well as several other gene modules pertaining to inflammation, complement activation, and epidermal activation and differentiation. The interferon (IFN)-inducible genes within the DM signature were present not only in DM and lupus, but also cutaneous herpes simplex-2 infection and to a lesser degree, psoriasis. This IFN signature was absent or weakly present in atopic dermatitis, allergic contact dermatitis, acne vulgaris, systemic sclerosis, and localized scleroderma/morphea. We observed that the IFN signature in DM skin appears to be more closely related to type I than type II IFN based on in vitro IFN stimulation expression signatures. However, quantitation of IFN mRNAs in DM skin shows that the majority of known type I IFNs, as well as IFN gamma, are overexpressed in DM skin. In addition, both IFN-beta and IFN-gamma (but not other type I IFN) transcript levels were highly correlated with the degree of the in vivo IFN transcriptional response in DM skin.
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| Overall design |
disease_state_design
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| Contributor(s) |
Fiorentino D |
| Citation(s) |
22235269 |
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| Submission date |
Sep 20, 2011 |
| Last update date |
Mar 23, 2012 |
| Contact name |
David Fiorentino |
| E-mail(s) |
fiorentino@stanford.edu
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| Phone |
650-498-6120
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| Fax |
650-723-7796
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| Organization name |
Stanford University
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| Department |
Dermatology
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| Lab |
Blake Wilbur Clinic, W0074
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| Street address |
900 Blake Wilbur Drive
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (3) |
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| Samples (54)
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| Relations |
| BioProject |
PRJNA147367 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32245_RAW.tar |
11.9 Mb |
(http)(custom) |
TAR |
| Processed data included within Sample table |
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