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Status |
Public on Jan 12, 2012 |
Title |
Fiorentino 2006-7 dermatomyositis, lupus, control skin |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Background: Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood. Methodology and Findings: We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of interferon (IFN)-inducible genes in DM skin, as well as several other gene modules pertaining to inflammation, complement activation, and epidermal activation and differentiation. The interferon (IFN)-inducible genes within the DM signature were present not only in DM and lupus, but also cutaneous herpes simplex-2 infection and to a lesser degree, psoriasis. This IFN signature was absent or weakly present in atopic dermatitis, allergic contact dermatitis, acne vulgaris, systemic sclerosis, and localized scleroderma/morphea. We observed that the IFN signature in DM skin appears to be more closely related to type I than type II IFN based on in vitro IFN stimulation expression signatures. However, quantitation of IFN mRNAs in DM skin shows that the majority of known type I IFNs, as well as IFN gamma, are overexpressed in DM skin. In addition, both IFN-beta and IFN-gamma (but not other type I IFN) transcript levels were highly correlated with the degree of the in vivo IFN transcriptional response in DM skin.
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Overall design |
disease_state_design
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Contributor(s) |
Fiorentino D |
Citation(s) |
22235269 |
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Submission date |
Sep 20, 2011 |
Last update date |
Mar 23, 2012 |
Contact name |
David Fiorentino |
E-mail(s) |
fiorentino@stanford.edu
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Phone |
650-498-6120
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Fax |
650-723-7796
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Organization name |
Stanford University
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Department |
Dermatology
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Lab |
Blake Wilbur Clinic, W0074
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Street address |
900 Blake Wilbur Drive
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City |
Stanford |
State/province |
CA |
ZIP/Postal code |
94305 |
Country |
USA |
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Platforms (3) |
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Samples (54)
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Relations |
BioProject |
PRJNA147367 |
Supplementary file |
Size |
Download |
File type/resource |
GSE32245_RAW.tar |
11.9 Mb |
(http)(custom) |
TAR |
Processed data included within Sample table |
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