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Series GSE3280 Query DataSets for GSE3280
Status Public on May 31, 2006
Title Expression profiling of leukemia cell lines
Organism Homo sapiens
Experiment type Expression profiling by array
Methylation profiling by array
Summary Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor-suppressor genes. Genome wide methylation profiling of myeloid leukemia cell lines identified a large number of genes with aberrantly methylated CpG islands. Comparative mRNA expression analysis suggests that more than half of these genes show extremely low or absent expression in normal cells, suggesting that hypermethylation in cancer may be independent of the transcriptional status of the affected gene.
Keywords: comparison of expression status and CpG methylation status
 
Overall design The expression profiles of the three leukemia cell lines KG-1, U937 and THP-1 was compared to normal human blood monocytes (reference). The set includes a single hybridization for each sample.
 
Contributor(s) Gebhard C, Schwarzfischer L, Rehli M
Citation(s) 16778185
Submission date Sep 09, 2005
Last update date Mar 25, 2019
Contact name Michael Rehli
E-mail(s) michael.rehli@klinik.uni-r.de
Organization name University Hospital Regensburg
Department Internal Med III
Street address F.-J.-Strauss-Allee 11
City Regensburg
ZIP/Postal code 93042
Country Germany
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (4)
GSM73641 human blood monocytes
GSM73642 KG-1
GSM73644 THP-1
Relations
BioProject PRJNA92937

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Supplementary data files not provided

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