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| Status |
Public on Jul 24, 2012 |
| Title |
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in vivo that transcription factors inducing epithelial-mesenchymal transition can drive the development of claudin-low tumors from differentiated mammary epithelial cells, by playing a dual role in cell transformation and dedifferentiation.
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| Overall design |
Gene expression profiles of three independent Twist1 + Ras- transgenic mouse-derived metaplastic breast tumors (Breast Tumor A, B and C) and of two luminal MMTV-ERBB2/Neu-breast tumor-derived cell lines (1 and 2) were determined.
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| |
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| Contributor(s) |
Morel A, Ansieau S, Puisieux A, Wierinckx A, Lachuer J, Nazaret N, Carrere M, Hinkal GW, Lamblot C |
| Citation(s) |
22654675 |
| |
| Submission date |
Oct 12, 2011 |
| Last update date |
Feb 11, 2019 |
| Contact name |
stéphane ansieau |
| E-mail(s) |
ansieau@lyon.fnclcc.fr
|
| Phone |
0033-478785160
|
| Fax |
0033-478782821
|
| Organization name |
Inserm U590
|
| Department |
Centre Léon Bérard
|
| Street address |
28 rue Laennec
|
| City |
Lyon |
| ZIP/Postal code |
69008 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (5)
|
| GSM814510 |
Twist1 + Ras- transgenic mouse derived mammary tumor A |
| GSM814511 |
Twist1 + Ras- transgenic mouse derived mammary tumor B |
| GSM814512 |
Mouse Breast cancer tumor cell line 1 |
| GSM814513 |
Mouse Breast cancer tumor cell line 2 |
| GSM879437 |
Twist1 + Ras- transgenic mouse derived mammary tumor C |
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| This SubSeries is part of SuperSeries: |
| GSE32905 |
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors |
|
| Relations |
| BioProject |
PRJNA154399 |
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