|
| Status |
Public on Sep 20, 2005 |
| Title |
Integrative Genomic and Proteomic Analysis of Prostate Cancer Reveals Signatures of Metastatic Progression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
An integrative analysis of this compendium of proteomic alterations and transcriptomic data was performed revealing only 48-64% concordance between protein and transcript levels. Importantly, differential proteomic alterations between metastatic and clinically localized prostate cancer that mapped concordantly to gene transcripts served as predictors of clinical outcome in prostate cancer as well as other solid tumors.
Keywords: prostate cancer progression
|
| |
|
| Overall design |
13 individual benign prostate, primary and metastatic prostate cancer samples and 6 pooled samples from benign,primary or metastatic prostate cancer tissues.
|
| |
|
| Contributor(s) |
Varambally S, Yu J, Laxman B, Mehra R, Tomlins SA, Chinnaiyan AM |
| Citation(s) |
16286247 |
| |
| Submission date |
Sep 17, 2005 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Jianjun Yu |
| E-mail(s) |
jianjun@umich.edu
|
| Phone |
734-615-1780
|
| Organization name |
University of Michigan
|
| Department |
Pathology
|
| Lab |
Dr. Arul Chinnaiyan
|
| Street address |
1150 W. Medical Center Dr.
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (19)
|
| GSM74878 |
Benign prostate tissue N4 |
| GSM74879 |
Benign prostate tissue NX1 |
| GSM74880 |
Benign prostate tissue NX2 |
| GSM74881 |
Clinically localized primary prostate cancer P1 |
| GSM74882 |
Clinically localized primary prostate cancer P2 |
| GSM74883 |
Clinically localized primary prostate cancer P3 |
| GSM74884 |
Clinically localized primary prostate cancer P4 |
| GSM74885 |
Clinically localized primary prostate cancer P5 |
| GSM74886 |
Clinically localized primary prostate cancer tissue pool PX1 |
| GSM74887 |
Clinically localized primary prostate cancer tissue pool PX2 |
| GSM74888 |
Metastatic prostate cancer W1 |
| GSM74889 |
Metastatic prostate cancer W2 |
| GSM74890 |
Metastatic prostate cancer W3 |
| GSM74891 |
Metastatic prostate cancer W4 |
| GSM74892 |
Metastatic prostate cancer tissue pool WX1 |
| GSM74893 |
Metastatic prostate cancer tissue pool WX2 |
|
| Relations |
| BioProject |
PRJNA93223 |
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