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| Status |
Public on Oct 20, 2012 |
| Title |
Analysis of genome-wide methylation of phenotypically discordant monozygotic twins |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Human intelligence demonstrates one of the highest heritabilities among human quantitative traits. Phenotypically discordant monozygotic twins provide a way to identify loci reponsible for the phenotypical differences.
We performed comprehensive DNA methylation analysis in monozygotic twins manifesting differences in IQ scores. Genes with significantly different methylation status are considered as candidates related to human intelligence.
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| Overall design |
Methylation profiling was conducted using methylated DNA enriched fraction by MethylMiner. Subjects were compared with their co-twins by MAT software and bed files were generated. Significantly high methyalted regions with MAT score p value < 0.000001 in each twin pairs were extracted as candidates.
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| Contributor(s) |
Yu C, Furukawa M, Kobayashi K, Shikizima C, Ando J, Toda T |
| Citation(s) |
23082141 |
| Submission date |
Nov 04, 2011 |
| Last update date |
Jan 21, 2015 |
| Contact name |
Chihchieh Yu |
| E-mail(s) |
ccyu@med.kobe-u.ac.jp
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| Organization name |
Kobe University
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| Street address |
7-5-1 kusunoki-cho, chuo-ku
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| City |
Kobe-shi |
| ZIP/Postal code |
6500017 |
| Country |
Japan |
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| Platforms (1) |
| GPL5082 |
[Hs_PromPR] Affymetrix Human Promoter 1.0R Array |
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| Samples (34)
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| This SubSeries is part of SuperSeries: |
| GSE33478 |
Genome-wide DNA methylation and gene expression analyses of monozygotic twin discordant for intelligence levels |
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| Relations |
| BioProject |
PRJNA154285 |
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