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| Status |
Public on Oct 25, 2005 |
| Title |
Comparison of monocytes from G-CSF mobilized and normal peripheral blood |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
A prospective randomized trial has shown that there is a survival advantage for allogeneic transplant patients receiving Granulocyte Colony Stimulating Factor (G-CSF) stimulated peripheral blood mononuclear cells (GPBMC) versus bone marrow (BM) as a source of stem cells. The biological basis for this advantage is not clear, and may be attributable to qualitative as well as quantitative differences in the CD34 cells, T-cells and/or the monocytes transplanted. To begin to address this issue, gene expression patterns in monocytes isolated from G-CSF mobilized peripheral blood were compared those from normal, non-mobilized peripheral blood to identify functional pathways that may distinguish these two populations.
Keywords: Cell type comparison
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| Overall design |
Six samples were analyzed, 3 from normal peripheral blood donors and 3 from normal donors who had been treated with G-CSF by a protocol designed to mobilize bone marrow stem cells into the peripheral blood.
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| Contributor(s) |
Graf L, Torok-Storb B, Heimfeld S, Iwata M, Kahl C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 17, 2005 |
| Last update date |
Jan 18, 2013 |
| Contact name |
Lynn Graf |
| E-mail(s) |
lgraf@fhcrc.org
|
| Phone |
206-667-4545
|
| Fax |
206-667-5978
|
| URL |
http://none
|
| Organization name |
Fred Hutchinson Cancer Research Center
|
| Department |
Clinical Research Division
|
| Lab |
Torok-Storb
|
| Street address |
1100 Fairview Ave. N. D1-100
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL44 |
FHCRC Human 18K Array |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA93405 |
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