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Series GSE36335 Query DataSets for GSE36335
Status Public on Mar 08, 2012
Title Distinct tumorigenic pathways within hereditary nonpolyposis colorectal cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Gene expression profiling has discriminated between sporadic microsatellite instable (MSI) and microsatellite stable (MSS) colorectal cancers (CRCs), whereas the expression pattern of familial colorectal cancer type X (FCCTX) and Lynch syndrome (LS) associated CRCs remain largely unknown. The purpose of this study is to use gene expression profiling of formalin-fixed paraffin-embedded (FFPE) tumor specimens from FCCTX, LS and sporadic CRC as a control to detect expression patterns and to identify signaling pathways differing between FCCTX and LS tumors.
 
Overall design RNA extracted from 132 FFPE specimens (40 FCCTX, 42 LS, 50 sporadic) were profiled for differential gene expression by the whole genome cDNA-mediated annealing, selection, extension, and ligation (WG-DASL) assay containing 18626 genes.
 
Contributor(s) Valentin MD, Therkildsen C, Veerla S, Jonsson M, Bernstein I, Borg A, Nilbert M
Citation(s) 23951239
Submission date Mar 07, 2012
Last update date Mar 12, 2018
Contact name Mev Dominguez
E-mail(s) mev_dv@yahoo.com
Phone +46 705792722
Organization name Lund University
Department Oncology
Lab BioMedical Center
Street address Klinikgatan 28
City Lund
State/province N/A
ZIP/Postal code SE-221 84, Lund
Country Sweden
 
Platforms (1)
GPL14951 Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip
Samples (132)
GSM889108 Familial colorectal cancer type X_25
GSM889109 Familial colorectal cancer type X_45
GSM889110 Familial colorectal cancer type X_20
Relations
BioProject PRJNA153389

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE36335_non-normalized.txt.gz 21.1 Mb (ftp)(http) TXT
Processed data included within Sample table

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