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| Status |
Public on Mar 16, 2012 |
| Title |
DNA methylation screening identifies driver epigenetic events of cancer cell survival. |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
Genome wide DNA methylation profiling of colon adenocarcinoma cell line HCT116 wild type and with a genetic disruption of DNMT3B and DNMT1 (DKO). The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. For this study, we used two DKO subclones, DKO8 and DKO1, which retain approximately 45% and 5% of the HCT116 wild type global DNA methylation levels, respectively
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| Overall design |
Bisulphite converted DNA from the 3 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2
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| Contributor(s) |
Jones P, De Carvalho D |
| Citation(s) |
22624715 |
| Submission date |
Mar 15, 2012 |
| Last update date |
Jan 02, 2015 |
| Contact name |
Daniel De Carvalho |
| E-mail(s) |
ddecarv@uhnresearch.ca
|
| Organization name |
Ontario Cancer Institute
|
| Street address |
101 College Street, room 9-302
|
| City |
Toronto |
| State/province |
ON |
| ZIP/Postal code |
M5G 1L7 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL8490 |
Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA153405 |
