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Status |
Public on Mar 17, 2012 |
Title |
Mll1 regulates the downstream gene transcription activated by TNFa |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Genes of mixed lineage leukemia family regulate transcription via methylating histone H3K4. we studied the role of MLL1 in innate immunity and found it selectively regulates the activation of NF-kB downstream genes mediated by TNFa.
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Overall design |
Mll1+/+ and Mll1-/- MEF cells were treated for 4 hr with 10ng/ml TNFa or control solution respectively. The same treatment were performed three times independently and the harvested cells of same treatment were mixed together and submitted for high throughput sequencing.
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Contributor(s) |
Wang X, Zhu K, Liao Y, Guo A, Li L, Wu M |
Citation(s) |
22623725 |
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Submission date |
Mar 16, 2012 |
Last update date |
May 15, 2019 |
Contact name |
Min Wu |
E-mail(s) |
wumin@whu.edu.cn
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Organization name |
Wuhan University
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Department |
College of Life Science
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Street address |
Room 5005, College of Life Sciences, Wuhan University
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City |
Wuhan |
State/province |
Hubei |
ZIP/Postal code |
430072 |
Country |
China |
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Platforms (1) |
GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
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Samples (4)
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Relations |
SRA |
SRP011556 |
BioProject |
PRJNA153723 |