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Series GSE36577 Query DataSets for GSE36577
Status Public on Aug 14, 2012
Title Chromosomal aberration of asbestos-induced malignant mesothelioma in rats
Organism Rattus norvegicus
Experiment type Genome variation profiling by genome tiling array
Summary Exposure to asbestos is a risk for malignant mesothelioma in humans. We carried out array comparative genomic hybridization (CGH) analysis in a rat model by repeated intraperitoneal injections of three types of asbestos including chrysotile, crocidolite and amosite. We found a common chromosomal deletion mapped to the chromosome 5q32 locus, containing the genes encoding tumour suppressor genes CDKN2A/2B/ARF. Homozygous deletion of CDKN2A/2B/ARF was observed in the majority (92.6%) of the rat MM samples.
Overall design Carcinogenesis protocol was performed using specific pathogen-free male and female F1 hybrid rats between Fischer344 and Brown-Norway strains. A total of 27 tumor samples were profiled on Agilent 244A aCGH arrays according to manufacturer's instructions for the screening purpose.
Contributor(s) Shinya T, Li J, Shinya A
Citation(s) 22864872
Submission date Mar 16, 2012
Last update date Jan 17, 2013
Contact name Shinya Toyokuni
Organization name Nagoya University
Department Pathology
Street address 65 Tsuruma-Cho, Showa-Ku
City Nagoya
State/province Aichi
ZIP/Postal code 466-8550
Country Japan
Platforms (1)
GPL15358 Agilent-015223 Rat Genome CGH Microarray 244A
Samples (27)
GSM897087 Malignant Mesothelioma Chry EM 1
GSM897088 Malignant Mesothelioma Chry EM 2
GSM897089 Malignant Mesothelioma Chry EM 3
BioProject PRJNA153737

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE36577_RAW.tar 1.7 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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