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Series GSE38172 Query DataSets for GSE38172
Status Public on Aug 01, 2012
Title Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Whole transcript expression was profiled using the Affymetrix 1.0 array in human bronchial epithelial cells exposed to PM collected from Saudi Arabia for 1 or 4 days. The differentially expressed genes were identified and analyzed for enriched networks and pathways using Ingenuity Pathway Analysis (IPA).
We have identified 140 and 230 genes that significantly changed more than 1.5 fold after PM exposure for 1 or 4 days, respectively. IPA analysis revealed that different exposure durations triggered distinct pathways. Genes involved in NRF2-mediated response to oxidative stress were up-regulated after 1 day exposure. In contrast, cells exposed for 4 days exhibited significantly changes in genes related to cholesterol and lipid synthesis pathways.
 
Overall design We analyzed gene expression profiles from 12 samples collected at two different time points, including 2 untreated controls, 2 normal PM treated samples and 2 storm PM treated samples for each time point.
 
Contributor(s) Sun H, Shamy M, Kluz T, Zhong M, Laulicht F, Alghamdi MA, Khoder MI, Chen L, Costa M
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Submission date May 23, 2012
Last update date Jul 26, 2018
Contact name Hong Sun
Organization name NYU School of Medicine
Department Medicine
Lab Sun Lab
Street address 341 East 25 Street
City New York
State/province NY
ZIP/Postal code 10010
Country USA
 
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (12)
GSM936215 untreated control samples collected at D1 #1
GSM936216 untreated control samples collected at D1 #2
GSM936217 normal PM treated samples collected at D1 after exposure #1
Relations
BioProject PRJNA167360

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38172_RAW.tar 56.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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