|
| Status |
Public on May 31, 2012 |
| Title |
JAK2 Naive and Persitent Murine BaF3 cells infected with MPLW515L |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcriptional profiling of Murine BaF3 cells infected with MPLW515L grown under either normal conditions (Naive) or in 0.8 uM INCB18424 for 4-6 weeks (Persistent). Naive and Persistent cells were then treated with either DMSO (Control) or 0.8 uM INCB18424 for 4 hours. Goal was to determine transcriptional changes conditioned upon sensitivity/resistance of BaF3 MPLW515L mutants to JAK1/2 specific inhibitor.
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| |
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| Overall design |
3 condition experiment consiting of: 1) Naive cells treated with DMSO (Control) , 2) Naïve cells treated with 0.8 uM INCB18424 for 4 hours (Acute) and 3) Persistent cells treated with 0.8 uM INCB18424 for 4 hours (Persistent). Biological replicates: 3 DMSO control replicates, 3 Acute replicates, 3 Persistent replicates.
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| |
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| Contributor(s) |
Levine R, Koppikar P |
| Citation(s) |
22820254 |
| |
| Submission date |
May 30, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Ross Levine |
| E-mail(s) |
leviner@mskcc.org
|
| Phone |
646-888-2767
|
| Fax |
646-422-0856
|
| Organization name |
Memorial Sloan-Kettering Cancer Center
|
| Department |
Human Oncology & Pathogenesis Program
|
| Lab |
Dr. Ross Levine
|
| Street address |
408 E. 69th St. ZRC-519
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (9)
|
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| Relations |
| BioProject |
PRJNA167738 |
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