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Series GSE38347 Query DataSets for GSE38347
Status Public on Dec 31, 2012
Title Genome-wide cistromes of thyroid hormone receptors alpha and beta in C17.2 cells
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Tagged versions of thyroid hormone receptors alpha (TRa) and beta (TRb) were stably transfected in two C17.2 cell lines, C17.2a and C17.2b, respectively. We performed an affinity-based purification of chromatin (ChAP), and high-throughput sequencing was used to assess binding sites of both receptors (ChAP-Seq). Standard ChIP-Seq for RXR was also performed in C17.2a cells. These data allow us to compare binding sites for both receptors and to conclude that they were only partially redundant, with co-existence of receptor-specific sites.
 
Overall design Examination of binding sites of the two thyroid hormone receptors (alpha, beta) in two cell lines (C17.2a, C17.2b), each expressing one of the receptors. Examination of RXR binding sites in C17.2a cells.
 
Contributor(s) Chatonnet F, Guyot R, Benoît G, Flamant F
Citation(s)
  • Chatonnet F, Guyot R, Benoît G, Flamant F. Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells. Proc Natl Acad Sci U S A 2013 Feb 19;110(8):E766-75. PMID: 23382204
Submission date May 30, 2012
Last update date May 15, 2019
Contact name Fabrice Chatonnet
E-mail(s) fabrice.chatonnet@ens-lyon.org
Phone +33 2 99 28 99 39
Organization name University Hospital of Rennes
Lab Inserm U1236 MICMAC
Street address 2 rue Henri le Guilloux
City Rennes
ZIP/Postal code 35033
Country France
 
Platforms (1)
GPL9185 Illumina Genome Analyzer (Mus musculus)
Samples (3)
GSM940399 ChAPSeq_TRa
GSM940400 ChAPSeq_TRb
GSM940401 ChIPSeq_RXR
This SubSeries is part of SuperSeries:
GSE41727 Genome-wide analysis of thyroid hormone receptors' shared and specific functions in neural cells
Relations
BioProject PRJNA167689
SRA SRP013451

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38347_RAW.tar 711.3 Mb (http)(custom) TAR (of BED, WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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