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Series GSE38864 Query DataSets for GSE38864
Status Public on May 04, 2015
Title A chromatin code for alternative splicing involving a putative association between CTCF and HP1α proteins
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Alternative splicing is primarily controlled by the activity of splicing factors and by the elongation of the RNA polymerase II (RNAPII). Recent experiments have suggested a new complex network of splicing regulation involving chromatin, transcription and multiple protein factors. In particular, the CCCTC-binding factor (CTCF), the Argonaute protein AGO1, and members of heterochromatin protein 1 (HP1) family have been implicated in the regulation of splicing associated to chromatin and the elongation of RNAPII. These results raise the question of whether these proteins may associate at the chromatin level to modulate alternative splicing.
 
Overall design RNA extraction from MCF-7 and MCF-10A cell lines. Splicing changes between these two cell lines were measured using a splice junction array (Affymetrix HJAY).
 
Contributor(s) Agirre E, Bellora N, Alló M, Pagès A, Bertucci P, Kornblihtt AR, Eyras E
Citation(s) 25934638
Submission date Jun 21, 2012
Last update date Aug 03, 2015
Contact name Eneritz Agirre
Organization name Karolinska Institutet
Department MBB
Lab Castelo-Branco, Molecular Neurobiology
Street address Solnavägen 9
City Stockholm
ZIP/Postal code 17165
Country Sweden
 
Platforms (1)
GPL15106 [hjay] Affymetrix GeneChip Human HJAY Array
Samples (6)
GSM950941 MCF10 1
GSM950942 MCF10 2
GSM950943 MCF10 3
This SubSeries is part of SuperSeries:
GSE60094 A chromatin code for alternative splicing involving an association between CTCF and HP1α proteins
Relations
BioProject PRJNA169147

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38864_Matrix_Processed_data.xls.gz 639.7 Kb (ftp)(http) XLS
GSE38864_RAW.tar 249.6 Mb (http)(custom) TAR (of CEL, CHP)
Processed data provided as supplementary file
Processed data are available on Series record

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