|
| Status |
Public on Mar 18, 2013 |
| Title |
Gene expression in pluripotent and TSKM-iPS induction cells. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We found that Tet1 (T) can substitute Oct4 and initiates somatic cell reprogramming in combination with Sox2 (S), Klf4 (K) and c-Myc (M). Moreover, the TSKM secondary reprogramming can proceed rapidly with widespread accompanying increase of 5hmC and 5mC at TSS and ES-active regulation regions followed by 5mC-5hmC pattern switchand, and the activation of endogenous Oct4 and Nanog was Tet1 and 5hmC involved in this process.
We used microarray to explore the global expression change during the reprogramming process
|
| |
|
| Overall design |
Examination of gene expression change in 3 different cell lines covering the main stages during the reprogramming process
|
| |
|
| Contributor(s) |
Gao Y, Chen J, Cai T, Gao S |
| Citation(s) |
23499384 |
| |
| Submission date |
Jul 25, 2012 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Tao Cai |
| E-mail(s) |
caitao@nibs.ac.cn
|
| Organization name |
National Institute Of Biological Sciences, Beijing (NIBS)
|
| Lab |
Sequencing Facility
|
| Street address |
No. 7 Science Park Road, Zhongguancun Life Science Park
|
| City |
Beijing |
| ZIP/Postal code |
102206 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (9)
|
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| This SubSeries is part of SuperSeries: |
| GSE39639 |
Gene expression and 5hmC/5mC state in pluripotent and TSKM-iPS induction cells |
|
| Relations |
| BioProject |
PRJNA171322 |
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