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| Status |
Public on Mar 08, 2013 |
| Title |
Milbemycins: more than efflux inhibitors for fungal pathogens |
| Platform organisms |
Candida albicans; Nakaseomyces glabratus CBS 138 |
| Sample organisms |
Candida albicans; Nakaseomyces glabratus |
| Experiment type |
Expression profiling by array
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| Summary |
This study investigated the effect of milbemycons as efflux inhibitors and antifungal agents. Milbemycin oxims can inhibit growth of Candida glabrata and C. albicans. The effect of milbemycins on transcriptomes was inbvestigated.
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| Overall design |
Gene expression was measured in C. glabrata milbemycin-treated cells (1h) and compared to untreated cells in the incubation mediun RPMI. The one-color system was used. Four biological replicates were used for each condition.
Gene expression was measured in C. albicans milbemycin-treated cells (1h) and compared to untreated cells in the incubation mediun RPMI. The one-color system was used. Three biological replicates were used for each condition.
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| Contributor(s) |
Sanglard D, Silva LV, Vandeputte P |
| Citation(s) |
23208712 |
| |
| Submission date |
Aug 20, 2012 |
| Last update date |
Jul 22, 2016 |
| Contact name |
Dominique Sanglard |
| E-mail(s) |
Dominique.Sanglard@chuv.ch
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| URL |
http://www.chuv.ch/imul
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| Organization name |
University of Lausanne and University Hospital Center
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| Street address |
Rue Bugnon 48
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| City |
Lausanne |
| ZIP/Postal code |
1011 |
| Country |
Switzerland |
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| Platforms (2) |
| GPL10713 |
IMUL-Candida glabrata 8x15k |
| GPL15960 |
Agilent-037331 Copy_of_C. albicans assembly 21_017942 [ORF name version] |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA173240 |
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