|
| Status |
Public on Aug 25, 2012 |
| Title |
Lack of local vitamin D synthesis accelerates breast cancer development after Cyp27B1 gene ablation in mammary epithelium |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The ablated Cyp27b1 mice showed no difference in mammary development but tumorigenesis was significantly accelerated. Cell proliferation, angiogenesis, cell cycle progression and survival markers were upregulated by Cyp27b1 ablation, a pattern confirmed by microarray analysis.
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| |
|
| Overall design |
Triplicate samples each of control mice and Cyp27b1 knockout mice.
|
| |
|
| Contributor(s) |
Kremer R, Li J |
| Citation missing |
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| |
| Submission date |
Aug 24, 2012 |
| Last update date |
Jan 16, 2019 |
| Contact name |
greg VOISIN |
| E-mail(s) |
voisingreg@yahoo.fr
|
| Organization name |
Centre Hospitalier de l'Université de Montréal Hôtel Dieu
|
| Department |
Département de Médecine, Centre de Recherche
|
| Lab |
physiologie pulmonaire
|
| Street address |
3840 Saint-Urbain
|
| City |
Montréal |
| State/province |
QC |
| ZIP/Postal code |
H2W 1T6 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA173796 |
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