NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE40734 Query DataSets for GSE40734
Status Public on Sep 30, 2012
Title The effect on gene expression of Smchd1 deletion in primary MEFs, transformed MEFs and MEF tumours
Organism Mus musculus
Experiment type Expression profiling by array
Summary Smchd1 appears to act as a tumour suppressor in the transformed fibroblast model. We find gene expression differences are most pronounced in the transformed MEFs. We always detect a small number of clustered genes and imprinted genes as differentially expressed, along with others involved in tumorigenesis.
 
Overall design The microarrays compared Smchd1 null and Smchd1 wildtype samples from different cell types (primary MEFs, transformed MEFs, tumours derived from transformed MEFs). Wildtype mice are FVB/N and Smchd1 null mice have the MommeD1 point mutation on a FBV/N background.
 
Contributor(s) Leong HS, Hu Y, Blewitt ME, Smyth GK
Citation(s) 23269277
Submission date Sep 10, 2012
Last update date Jan 16, 2019
Contact name Gordon K Smyth
E-mail(s) smyth@wehi.edu.au
Phone (+61 3) 9345 2326
Fax (+61 3) 9347 0852
URL http://www.wehi.edu.au
Organization name Walter and Eliza Hall Institute of Medical Research
Department Bioinformatics
Lab Smyth
Street address 1G Royal Pde
City Parkville
State/province Vic
ZIP/Postal code 3052
Country Australia
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (30)
GSM1000166 Primary MEF_Smchd1 wildtype_Rep 1
GSM1000167 Primary MEF_Smchd1 null_Rep 1
GSM1000168 Primary MEF_Smchd1 wildtype_Rep 2
This SubSeries is part of SuperSeries:
GSE40992 The effect on gene expression of Smchd1 deletion in various cell types
Relations
BioProject PRJNA174772

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40734_RAW.tar 15.8 Mb (http)(custom) TAR
GSE40734_control_probe_profile.txt.gz 374.9 Kb (ftp)(http) TXT
GSE40734_iltp2366_Sample_Probe_Profile.txt.gz 15.7 Mb (ftp)(http) TXT
GSE40734_non-normalized.txt.gz 5.7 Mb (ftp)(http) TXT
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap