|
| Status |
Public on Dec 01, 2007 |
| Title |
Histone turnover mediates epigenetic processes in Drosophila S2 cells |
| Organism |
Drosophila melanogaster |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
|
| Summary |
Histone H3 is assembled into nucleosomes during replication but is replaced by the H3.3 variant at sites of active transcription. Thus replacement levels provide a quantitative measure of histone turnover during transcriptional elongation and other active processes in dividing cells. Here we provide new insights into epigenetic regulation with the first genome-wide chromatin profile at 100-bp resolution, based on measurements of H3.3 levels throughout the Drosophila genome. These data are unpublished.
Keywords: Chromatin affinity-purification on microarray
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| |
|
| Overall design |
Chromatin affinity profiling of histones H3 and H3.3 on Drosophila tiling arrays
|
| Web link |
http://nettie.fhcrc.org/jorja/fly.html
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| |
|
| Contributor(s) |
Mito Y, Henikoff JG, Henikoff S |
| Citation(s) |
17347439 |
| |
| Submission date |
Jan 24, 2006 |
| Last update date |
Apr 18, 2012 |
| Contact name |
Jorja Henikoff |
| E-mail(s) |
jorja@fhcrc.org
|
| Phone |
206-667-4850
|
| Organization name |
Fred Hutchinson Cancer Research Center
|
| Department |
Basic Sciences
|
| Lab |
Henikoff
|
| Street address |
1100 Fairview AV N, A1-162
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109-1024 |
| Country |
USA |
| |
|
| Platforms (3) |
| GPL3352 |
FHCRC DMEL 4.2 Tiling 1 of 3 |
| GPL3353 |
FHCRC DMEL 4.2 Tiling 2 of 3 |
| GPL3354 |
FHCRC DMEL 4.2 Tiling 3 of 3 |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA95249 |
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