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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 08, 2013 |
| Title |
Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Mitochondria control bioenergetics and cell fate decisions, but whether they also participate in extra-organelle signaling is not understood. Here, we show that interference with cyclophilin D (CypD), a mitochondrial matrix protein and apoptosis regulator, causes accelerated cell proliferation and enhanced cell migration and invasion. These responses are associated with global transcriptional changes in CypD-/- cells, predominantly affecting chemokines and their receptors, and resulting in increased activating phosphorylation of Signal Transduction and Activator of Transcription 3 (STAT3). In turn, STAT3 signaling promotes increased proliferation of CypD-/- cells via accelerated S-phase entry and supports Cxcl12-directed paracrine cell motility. Therefore, mitochondria-to-nuclei transcriptional signaling globally affects cell division and motility. As immunosuppressive therapies often target CypD, this pathway may predispose the tissue microenvironment of these patients to oncogenic transformation.
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| Overall design |
Three wild type (WT) and three CypD-/- knock-out mouse embryonic fibroblasts (MEFs) have been compared.
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| Contributor(s) |
Altieri DC |
| Citation(s) |
23303179 |
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| Submission date |
Oct 02, 2012 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Louise C Showe |
| E-mail(s) |
lshowe@wistar.org
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| Phone |
215-898-3791
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| Organization name |
The Wistar Institute
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| Lab |
Dr. Louise Showe
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| Street address |
3601 Spruce St
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA176452 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE41280_RAW.tar |
17.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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