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| Status |
Public on Mar 08, 2013 |
| Title |
Transcriptional profiling of tumor-associated blood vessels in invasive bladder cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Tumor-associated blood vessels differ from normal vessels at the morphological and molecular level. Proteins that are only present on tumor vessels may serve as biomarkers and as therapeutic targets for inhibition of angiogenesis in cancer. Comparing the transcriptional profiles of blood vascular endothelium from human invasive bladder cancer and from normal bladder tissue, we found several markers that could serve as novel biomarkers or therapeutic targets.
In this dataset, we include the expression data obtained from laser capture microdissected (LCM) vessels isolated from tumor and bladder normal tissue.
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| |
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| Overall design |
10 samples were analyzed. We compared expression of tumor associated blood vessels with expression of vessels in the normal bladder tissue using Genespring GX 12.
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| Contributor(s) |
Roudnicky F, Poyet C, Detmar M |
| Citation(s) |
23243026 |
| |
| Submission date |
Oct 16, 2012 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Filip Roudnicky |
| E-mail(s) |
filip.roudnicky@pharma.ethz.ch
|
| Phone |
+41 44 633 73 14
|
| Fax |
+41 44 633 13 64
|
| Organization name |
Swiss Federal Institute of Technology
|
| Department |
Institute of Pharmaceutical Sciences
|
| Lab |
Pharmacogenomics
|
| Street address |
Langwiesstrasse 25
|
| City |
Zurich |
| ZIP/Postal code |
8093 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL5175 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (10)
|
| GSM1020196 |
isolated blood vessels from normal bladder; patient 6 |
| GSM1020197 |
isolated blood vessels from bladder cancer; patient 6 |
| GSM1020198 |
isolated blood vessels from normal bladder; patient 7 |
| GSM1020199 |
isolated blood vessels from bladder cancer; patient 7 |
| GSM1020200 |
isolated blood vessels from normal bladder; patient 12 |
| GSM1020201 |
isolated blood vessels from bladder cancer; patient 12 |
| GSM1020202 |
isolated blood vessels from normal bladder; patient 14 |
| GSM1020203 |
isolated blood vessels from bladder cancer; patient 14 |
| GSM1020204 |
isolated blood vessels from bladder cancer; patient 16 |
| GSM1020205 |
isolated blood vessels from normal bladder; patient 21 |
|
| Relations |
| BioProject |
PRJNA177693 |
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