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Series GSE41649 Query DataSets for GSE41649
Status Public on Oct 18, 2012
Title Comparison of two sets of microarray experiments to define allergic asthma expression pattern
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Allergic asthma is a complex trait. Several approaches have been used to identify biomarkers involved in this disease. This study aimed at demonstrating the relevance and validity of microarrays in the definition of allergic asthma expression pattern. The authors compared the transcript expressions of bronchial biopsy of 2 different microarray experiments done 2 years apart, both including nonallergic healthy and allergic asthmatic subjects (n = 4 in each experiment). U95Av2 and U133A GeneChips detected respectively 89 and 40 differentially expressed genes. Fifty-five percent of the U133A genes were previously identified with the U95Av2 arrays. The immune signaling molecules and the proteolytic enzymes were the most preserved categories between the 2 experiments, because 3/4 of the genes identified by the U133A were also significant in the U95Av2 study for both categories. These results demonstrate the relevance of microarray experiments using bronchial tissues in allergic asthma. The comparison of these GeneChip studies suggests that earlier microarray results are as relevant as actual ones to target new genes of interest, particularly in function categories linked to the studied disease. Moreover, it demonstrates that microarrays are a valuable technology to target novel allergic asthma pathways as well as biomarkers.
 
Overall design 4 healthy controls without history of allergy and asthma and 4 allergic asthmatic subjects according to the American Thoracic Society (ATS) criteria were selected
 
Contributor(s) Chamberland A, Madore A, Tremblay K, Laviolette M, Laprise C
Citation(s) 19842841
Submission date Oct 17, 2012
Last update date Aug 10, 2018
Contact name Catherine Laprise
Organization name Université du Québec à Chicoutimi
Street address 555 Boul. Université
City Chicoutimi
State/province Qc
ZIP/Postal code G7H 2B1
Country Canada
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (8)
GSM1020960 c.1
GSM1020961 c.2
GSM1020962 c.3
Relations
BioProject PRJNA177814

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Supplementary file Size Download File type/resource
GSE41649_RAW.tar 26.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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