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Status |
Public on Oct 24, 2013 |
Title |
Remission in Juvenile Idiopathic Arthritis Achieved on Different Drug Regimens |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Remission has become both the gold standard for clinical care and the end point for clinical trials for children with juvenile idiopathic arthritis (JIA). Using gene expression microarrays, we found that when remission induced by methotrexate (MTX) or MTX plus a TNF inhibitor (etanercept, Et) (MTX+Et) was compared with healthy controls, there were notable differences in gene expression patterns, demonstrating that remission is not a restoration of immunologic normalcy. Differences were detected in PBMC as well as in granulocytes.
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Overall design |
Total RNA was extracted from isolated PBMC and granulocytes from patients with polyarticular JIA and from healthy controls. Patients had achieved remission (clinical remission on medicine as defined by Wallace et al, Arthritis Rheum. 2005;52(11):3354-3562) using either MTX or MTX+Et.
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Contributor(s) |
Frank B |
Citation missing |
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Submission date |
Oct 24, 2012 |
Last update date |
Mar 25, 2019 |
Contact name |
Bart Frank |
E-mail(s) |
frank@omrf.org
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Organization name |
OMRF
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Street address |
825 NE 13 St
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City |
Oklahoma City |
State/province |
OK |
ZIP/Postal code |
73103 |
Country |
USA |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (78)
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GSM1025129 |
granulocyte, healthy control, biological rep1 |
GSM1025130 |
granulocyte, healthy control, biological rep2 |
GSM1025131 |
granulocyte, healthy control, biological rep3 |
GSM1025132 |
granulocyte, healthy control, biological rep4 |
GSM1025133 |
granulocyte, healthy control, biological rep5 |
GSM1025134 |
granulocyte, healthy control, biological rep6 |
GSM1025135 |
granulocyte, healthy control, biological rep7 |
GSM1025136 |
granulocyte, healthy control, biological rep8 |
GSM1025137 |
granulocyte, healthy control, biological rep9 |
GSM1025138 |
granulocyte, healthy control, biological rep10 |
GSM1025139 |
granulocyte, healthy control, biological rep11 |
GSM1025140 |
granulocyte, healthy control, biological rep12 |
GSM1025141 |
granulocyte, healthy control, biological rep13 |
GSM1025142 |
granulocyte, patient. Mtx rep1 |
GSM1025143 |
granulocyte, patient. Mtx rep2 |
GSM1025144 |
granulocyte, patient. Mtx rep3 |
GSM1025145 |
granulocyte, patient. Mtx rep4 |
GSM1025146 |
granulocyte, patient. Mtx rep5 |
GSM1025147 |
granulocyte, patient. Mtx rep6 |
GSM1025148 |
granulocyte, patient. Mtx rep7 |
GSM1025149 |
granulocyte, patient. Mtx rep8 |
GSM1025150 |
granulocyte, patient. Mtx rep9 |
GSM1025151 |
granulocyte, patient. Mtx rep10 |
GSM1025152 |
granulocyte, patient. Mtx+Et rep1 |
GSM1025153 |
granulocyte, patient. Mtx+Et rep2 |
GSM1025154 |
granulocyte, patient. Mtx+Et rep3 |
GSM1025155 |
granulocyte, patient. Mtx+Et rep4 |
GSM1025156 |
granulocyte, patient. Mtx+Et rep5 |
GSM1025157 |
granulocyte, patient. Mtx+Et rep6 |
GSM1025158 |
granulocyte, patient. Mtx+Et rep7 |
GSM1025159 |
granulocyte, patient. Mtx+Et rep8 |
GSM1025160 |
granulocyte, patient. Mtx+Et rep9 |
GSM1025161 |
granulocyte, patient. Mtx+Et rep10 |
GSM1025162 |
granulocyte, patient. Mtx+Et rep11 |
GSM1025163 |
granulocyte, patient. Mtx+Et rep12 |
GSM1025164 |
PBMC, healthy control, biological rep1 |
GSM1025165 |
PBMC, healthy control, biological rep2 |
GSM1025166 |
PBMC, healthy control, biological rep3 |
GSM1025167 |
PBMC, healthy control, biological rep4 |
GSM1025168 |
PBMC, healthy control, biological rep5 |
GSM1025169 |
PBMC, healthy control, biological rep6 |
GSM1025170 |
PBMC, healthy control, biological rep7 |
GSM1025171 |
PBMC, healthy control, biological rep8 |
GSM1025172 |
PBMC, healthy control, biological rep9 |
GSM1025173 |
PBMC, healthy control, biological rep10 |
GSM1025174 |
PBMC, healthy control, biological rep11 |
GSM1025175 |
PBMC, healthy control, biological rep12 |
GSM1025176 |
PBMC, healthy control, biological rep13 |
GSM1025177 |
PBMC, healthy control, biological rep14 |
GSM1025178 |
PBMC, healthy control, biological rep15 |
GSM1025179 |
PBMC, patient. Mtx rep1 |
GSM1025180 |
PBMC, patient. Mtx rep2 |
GSM1025181 |
PBMC, patient. Mtx rep3 |
GSM1025182 |
PBMC, patient. Mtx rep4 |
GSM1025183 |
PBMC, patient. Mtx rep5 |
GSM1025184 |
PBMC, patient. Mtx rep6 |
GSM1025185 |
PBMC, patient. Mtx rep7 |
GSM1025186 |
PBMC, patient. Mtx rep8 |
GSM1025187 |
PBMC, patient. Mtx rep9 |
GSM1025188 |
PBMC, patient. Mtx rep10 |
GSM1025189 |
PBMC, patient. Mtx rep11 |
GSM1025190 |
PBMC, patient. Mtx rep12 |
GSM1025191 |
PBMC, patient. Mtx rep13 |
GSM1025192 |
PBMC, patient. Mtx rep14 |
GSM1025193 |
PBMC, patient. Mtx+Et rep1 |
GSM1025194 |
PBMC, patient. Mtx+Et rep2 |
GSM1025195 |
PBMC, patient. Mtx+Et rep3 |
GSM1025196 |
PBMC, patient. Mtx+Et rep4 |
GSM1025197 |
PBMC, patient. Mtx+Et rep5 |
GSM1025198 |
PBMC, patient. Mtx+Et rep6 |
GSM1025199 |
PBMC, patient. Mtx+Et rep7 |
GSM1025200 |
PBMC, patient. Mtx+Et rep8 |
GSM1025201 |
PBMC, patient. Mtx+Et rep9 |
GSM1025202 |
PBMC, patient. Mtx+Et rep10 |
GSM1025203 |
PBMC, patient. Mtx+Et rep11 |
GSM1025204 |
PBMC, patient. Mtx+Et rep12 |
GSM1025205 |
PBMC, patient. Mtx+Et rep13 |
GSM1025206 |
PBMC, patient. Mtx+Et rep14 |
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Relations |
BioProject |
PRJNA178263 |
Supplementary file |
Size |
Download |
File type/resource |
GSE41831_RAW.tar |
389.6 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
Processed data included within Sample table |
Processed data provided as supplementary file |
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