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Series GSE41831 Query DataSets for GSE41831
Status Public on Oct 24, 2013
Title Remission in Juvenile Idiopathic Arthritis Achieved on Different Drug Regimens
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Remission has become both the gold standard for clinical care and the end point for clinical trials for children with juvenile idiopathic arthritis (JIA). Using gene expression microarrays, we found that when remission induced by methotrexate (MTX) or MTX plus a TNF inhibitor (etanercept, Et) (MTX+Et) was compared with healthy controls, there were notable differences in gene expression patterns, demonstrating that remission is not a restoration of immunologic normalcy. Differences were detected in PBMC as well as in granulocytes.
 
Overall design Total RNA was extracted from isolated PBMC and granulocytes from patients with polyarticular JIA and from healthy controls. Patients had achieved remission (clinical remission on medicine as defined by Wallace et al, Arthritis Rheum. 2005;52(11):3354-3562) using either MTX or MTX+Et.
 
Contributor(s) Frank B
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Oct 24, 2012
Last update date Mar 25, 2019
Contact name Bart Frank
E-mail(s) frank@omrf.org
Organization name OMRF
Street address 825 NE 13 St
City Oklahoma City
State/province OK
ZIP/Postal code 73103
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (78)
GSM1025129 granulocyte, healthy control, biological rep1
GSM1025130 granulocyte, healthy control, biological rep2
GSM1025131 granulocyte, healthy control, biological rep3
Relations
BioProject PRJNA178263

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41831_RAW.tar 389.6 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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