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| Status |
Public on Sep 12, 2013 |
| Title |
Gene expression analysis in TGFbeta/TNFalpha treated A549 spheroid cultures |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
TGFbeta/TNFalpha treated spheroid A549 cultures are a model of the epithelial-mesenchymal transition (EMT). These experiments capture the changes in global gene expression that result from cells being induced to undergo EMT (3D control vs 3D treated), but also the differences in gene expression when A549 is grown in spheroid cultures (2D control vs 3D untreated). EMT is efficiently induced only in the spheroid culture model.
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| Overall design |
A total of 8 samples are analyzed, corresponding to 4 conditions (2D control, 2D treated, 3D control, 3D treated) and 2 biological replicates.
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| Contributor(s) |
Mayo MW, Bekiranov S, Baranova N, Allison D, Wamsley J, Gray L, Chodaparambil S, Kumar M, Hoang S, Cieslik M, Xu X |
| Citation(s) |
24004852, 25432175 |
| |
| Submission date |
Nov 19, 2012 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Marcin Piotr Cieslik |
| E-mail(s) |
marcin.cieslik@gmail.com
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| Phone |
4343262626
|
| Fax |
4343262626
|
| Organization name |
University of Virginia
|
| Street address |
400 Stribling Ave Ext
|
| City |
Charlottesville |
| State/province |
VA |
| ZIP/Postal code |
22903 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE42375 |
chromatin reprogramming and differential gene expression in a model of EMT (spheroid A549 treated with TGF/TNF) |
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| Relations |
| BioProject |
PRJNA181206 |
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