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Series GSE42961 Query DataSets for GSE42961
Status Public on Dec 16, 2013
Title Determination of the spatial organization of the FXN gene locus by using Chromosome Conformation Capture technique coupled with High-throughtput sequencing (3C-seq).
Organism Homo sapiens
Experiment type Other
Summary Accumulating data from different groups have demonstrated that alteration of post-translational histone modifications is an important underlying mechanism for FXN silencing in FRDA. The relationship between chromatin architecture and histone modification marks in the FXN gene locus is likely to be important for understanding the silencing mechanism. We therefore investigated the spatial organization of the FXN gene locus using the 3C-sequencing method.
Overall design EBV transformed lymphoblastoid cell lines derived from patients (GM15850, GM16234 and GM16798) and Healthy control (GM14664 and GM15851) were used for generating 3C-seq libraries.
Contributor(s) Chan PK, Khadayate S
Citation(s) 23474817
Submission date Dec 17, 2012
Last update date May 15, 2019
Contact name Sanjay Padmakar Khadayate
Organization name MRC London Institute of Medical Sciences
Street address Du Cane Road
City London
ZIP/Postal code W12 0NN
Country United Kingdom
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (5)
GSM1054025 GM14664
GSM1054026 GM15851
GSM1054027 GM15850
BioProject PRJNA183944
SRA SRP017581

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Supplementary file Size Download File type/resource
GSE42961_RAW.tar 840.0 Kb (http)(custom) TAR (of BED)
GSE42961_supplementary_table_1.pdf.gz 90.8 Kb (ftp)(http) PDF
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Processed data provided as supplementary file

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