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| Status |
Public on Dec 23, 2012 |
| Title |
Eye imaginal disc expressing transgenic human proinsulin in Drosophila eye under regulation of GMR-GAL4 |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
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| Summary |
We used microarrays to detail the global program of gene expression in response to expression of either mutant (C96Y) or wild-type human proinsulin and identified distinct classes of up-regulated genes. Results provides insight into the molecular mechanisms underlying a form of neonatal diabetes.
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| Overall design |
Drosophila eye imaginal discs were selected at the wandering stage of 3rd instar larval development for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Park S, Ludwig M, Bell GI, Kreitman M |
| Citation(s) |
24281154 |
| Submission date |
Dec 22, 2012 |
| Last update date |
May 04, 2018 |
| Contact name |
Soo-Young Park |
| Organization name |
The University of Chicago
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| Department |
Medicine
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| Street address |
5841 S. Maryland Ave.
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| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
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| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
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| Samples (20)
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| GSM1057091 |
Non-transgenic fly, male biological rep1 |
| GSM1057092 |
Non-transgenic fly, male biological rep2 |
| GSM1057093 |
Non-transgenic fly, female biological rep1 |
| GSM1057094 |
Non-transgenic fly, female biological rep2 |
| GSM1057095 |
Transgenic fly line WT-6, male biological rep1 |
| GSM1057096 |
Transgenic fly line WT-6, male biological rep2 |
| GSM1057097 |
Transgenic fly line WT-6, female biological rep1 |
| GSM1057098 |
Transgenic fly line WT-6, female biological rep2 |
| GSM1057099 |
Transgenic fly line WT-24, male biological rep1 |
| GSM1057100 |
Transgenic fly line WT-24, male biological rep2 |
| GSM1057101 |
Transgenic fly line WT-24, female biological rep1 |
| GSM1057102 |
Transgenic fly line WT-24, female biological rep2 |
| GSM1057103 |
Transgenic fly line Mut-101, male biological rep1 |
| GSM1057104 |
Transgenic fly line Mut-101, male biological rep2 |
| GSM1057105 |
Transgenic fly line Mut-101, female biological rep1 |
| GSM1057106 |
Transgenic fly line Mut-101, female biological rep2 |
| GSM1057107 |
Transgenic fly line Mut-1, male biological rep1 |
| GSM1057108 |
Transgenic fly line Mut-1, male biological rep2 |
| GSM1057109 |
Transgenic fly line Mut-1, female biological rep1 |
| GSM1057110 |
Transgenic fly line Mut-1, female biological rep2 |
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| Relations |
| BioProject |
PRJNA184672 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE43128_RAW.tar |
45.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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