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| Status |
Public on Sep 30, 2014 |
| Title |
Strength training with suppressed testosterone level |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Human subjects were randomized for treatment with a GnRH-analogue, Goserelin, which suppresses endogenous testosterone or placebo for 12 weeks. Strength training was performed during the last 8 weeks. The suppression of testosterone resulted in an attenuation of the normal muscle adaptation to strength training (increased muscle mass and strength). To identify molecular signals involved in the response to testosterone levels, biopsies were obtained 4 hours after the last training session and gene expression compared with Affymetrix 3' microarrays. This timepoint should capture goserelin effect on both constitutive expression, training induced changes as well as acute exercise induced (4 hours) differences in mRNA levels.
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| Overall design |
Four subject from the placebo group and five subjects from the Goserelin group were compared. Total RNA from vastus lateralis mmuscle biopsies were purified and analyzed on Affymetrix HG-U133 Plus 2.0 arrays.
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| Contributor(s) |
Schjerling P, Kvorning T |
| Citation(s) |
25294097 |
| Submission date |
Jan 11, 2013 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Peter Schjerling |
| E-mail(s) |
Peter@mRNA.dk
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| Organization name |
Bispebjerg Hospital
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| Department |
Institute of Sports Medicine Copenhagen, ISMC
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| Street address |
Bispebjerg Bakke 23, M81
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| City |
Copenhagen |
| State/province |
--------- |
| ZIP/Postal code |
DK-2400 |
| Country |
Denmark |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA186419 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE43437_RAW.tar |
47.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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